It is possible that inhibition of cyclooxygenase cox1 is the major action of aspirin involved in its analgesic and antipyretic effects, and inhibition of cox2 is responsible for its antiinflammatory action. O vinculo entre a inflamacao e a carcinogenese pode ser visto como consistindo em duas vias. Cox2 is inducible isoform on 1q, has 61% sequence homology with cox1 regulated by mitogens, tumor promoters, cytokines, serum, free fatty acids, nsaids, selective. Eleccion del cable coaxial y sus distintas aplicaciones 7.
There are three different types of cox enzymes such as cox1, cox2 and cox3. Cyclooxygenases 1 cox1 and 2 cox2, also known as prostaglandin h synthase, catalyze formation of prostaglandin from arachidonic acid cox1 is constitutive form of enzyme on 9q. A new class of selective cyclooxygenase2 cox 2 inhibitors has been identified by high throughput screening. Expression of cox2 is regulated by growth factors, tumor promoters, bacterial endotoxin. Variantes del dielectrico y estandares del cable coaxial 4.
The compound sc75416 is a representative of this class. The difference between cox1 and cox2 is outlined below. They are similar in different aspects and have some differences too. There are several coxs cyclooxygenases produced by the body and cox1 and cox2 are the most important. Cox2 has been cloned from a variety of species including human, rat, and sheep and has a molecular weight of 72 kda. View humanmouse total cox2 cellbased elisa kcb4198 datasheet. Cox1 is also called as constitutive enzyme because it is produced by a cell under all types of physiological conditions. Cox2 is inducible isoform on 1q, has 61% sequence homology with cox1. Diferencia estructural entre cox1 y cox2 debida al. Cox1 produces prostaglandin e1 pge1, which causes pain and inflammation, but also plays a role in protecting the stomach lining. Ja a cox2 e estimulada em inflamacoes, cancer, etc. Evaluation of cox1cox2 selectivity and potency of a new. Assessment of cox2 selectivity there is a wide variety of assays to assess cox1 and cox2 selectivity. The human whole blood assay is probably the best available currently to assess inhibition of cox1 and cox2.